Neurochemical Studies on GABA Receptor (IV) Properties of Solubilized GABA Receptor
نویسندگان
چکیده
منابع مشابه
Locating GABA in GABA receptor binding sites.
The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (gamma-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABA(A) and GABA(C) receptors, and specific interactions between GABA and some of these residues have been determined. In the present paper, I show how...
متن کاملAn exciting GABA receptor
NATURE REVIEWS | NEUROSCIENCE VOLUME 4 | DECEMBER2003 | 937 GABA (γ-aminobutyric acid) is a classical inhibitory neurotransmitter, although it has been suggested that it might mediate excitation in some adult neurons. Beg and Jorgensen, writing in Nature Neuroscience, have characterized an unusual GABA receptor that is selective for cations rather than anions, giving it an excitatory effect. Th...
متن کاملAnalgesic effect of intracerebroventricular injection of GABA receptor agents and the role of opioid system
In the present study, the effect of GABA (γ-aminobutyric acid) receptor agonists and antagonists on morphine-induced antinociception was investigated in formalin test in rats. Intraperitoneal (i.p.) injection of different doses of morphine (1, 3, 6 and 9 mg/kg) and intracerebroventricular (i.c.v.) injection of different doses of muscimol (0.5, 1 and 2 g/rat) or baclofen (0.25, 0.5 and 1 g/rat) ...
متن کاملGABA(A) receptor channel pharmacology.
GABA(A) receptor channels are ubiquitous in the mammalian central nervous system mediating fast inhibitory neurotransmission by becoming permeant to chloride ions in response to GABA. The emphasis of this review is on the rich chemical diversity of ligands that influence GABA(A) receptor function. Such diversity provides many avenues for the design and development of new chemical entities actin...
متن کاملAntagonist properties of arylaminopyridazine GABA derivatives at the Ascaris muscle GABA receptor.
1. In a previous study, it was shown that the potency order for two arylamino-pyridazine derivatives, SR95531 and SR95103, was different in Ascaris suum when compared to vertebrate preparations. SR95531, the most potent analogue at the vertebrate GABAA receptor, was found to be very weak at antagonizing GABA responses in Ascaris, but SR95103, approximately 20 times less potent than SR95531 in v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1981
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)54447-x